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KMID : 0358320080490090813
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Korean Journal of Urology
2008 Volume.49 No. 9 p.813 ~ p.817
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The Relationship between Metabolic Syndrome and Prostate Volume in Men Over Sixties who Underwent Prostate Health Check-up
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Koo Kyo-Chul
Hong Sung-Joon
Cho Kang-Su
Kang Eun-Min
Kwon Sung-Won
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Abstract
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Purpose: To evaluate the relationship between factors of metabolic syndrome(MS) to prostate volume and lower urinary tract symptom in men over sixties.
Materials and Methods: A total of 624 male subjects aged 60 to 90 years were enrolled. Prostate volume, urinary flow rate, voided volume, post void residual urine volume, voiding symptoms and MS-related parameters were investigated. Patients were divided into two groups; those with MS (n=223) and those without(n=401). Prostate volume, urodynamic factors and voiding symptoms were compared based upon MS categories.
Results: The MS and control group showed no significant differences with respect to age(74.8±5.6 vs. 74.0±5.4, respectively, p=0.083) and prostate specific antigen levels(1.8±1.5 vs. 1.7±1.5, respectively, p=0.248). However, the MS group had significantly greater waist circumference, blood pressure, fasting blood sugar level, hypertriglyceridemia and lower high density lipoprotein(HDL) cholesterol than the control group(p＜0.05). Patients with MS showed significantly larger total prostate volume(p=0.008) and transitional zone volume(p=0.012). There were no differences between two groups respect to maximum flow rate, voided volume and residual volume (p＞0.05). There was a significant relationship between prostate volume and obesity(p=0.016), however other MS factors such as low HDL, hypertension, non-insulin dependent diabetes mellitus and hypertriglyceridemia were not associated with prostate volume(p＞0.05).
Conclusions: Metabolic syndrome is associated with prostate volume related factors, but not to voiding dysfunction in Korean men over sixties. Among subcategories of MS, obesity is the most strongly related factor to prostate volume.
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KEYWORD
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Metabolic syndrome X, Prostatic hyperplasia, Urination disorders, Obesity
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